Table 3.
Predicted participant-specific elimination rates and estimated half-life using adjusted generalized linear mixed models with random intercept for participants and random slope for time stratified by variables of interest
| Adjusted A Elimination Rate | Adjusted A Half-Life | |||||
|---|---|---|---|---|---|---|
|  | ||||||
| Stratified Variables | Median | 25th Percentile. | 75th Percentile. | Median | 25th Percentile | 75th Percentile | 
|  | ||||||
| Initial Measurement B | ||||||
| <75th Percentile (i=1487) | 0.0582 | 0.0538 | 0.0610 | 11.90 | 11.36 | 12.87 | 
| ≥75th Percentile (i=487) | 0.0518 | 0.0452 | 0.0569 | 13.37 | 12.18 | 15.15 | 
| Sex | ||||||
| Male (i=1004) | 0.0619 | 0.0581 | 0.0661 | 11.20 | 10.49 | 11.94 | 
| Female (i=970) | 0.0504 | 0.0462 | 0.0526 | 13.75 | 13.15 | 14.99 | 
| Age at exposure | ||||||
| 16 – 25 years (i=551) | 0.0443 | 0.0437 | 0.0457 | 15.65 | 15.17 | 15.86 | 
| 25 – <50 years (i=991) | 0.0567 | 0.0514 | 0.0606 | 12.23 | 11.41 | 13.47 | 
| ≥50 years (i=432) | 0.0673 | 0.0573 | 0.0725 | 10.29 | 9.54 | 12.10 | 
| Body Mass Index C | ||||||
| <75th Percentile (i=1480) | 0.0573 | 0.0537 | 0.0607 | 12.09 | 11.41 | 12.91 | 
| ≥75th Percentile (i=494) | 0.0536 | 0.0466 | 0.0556 | 12.94 | 12.42 | 14.85 | 
| Smoking | ||||||
| Never (i=1097) | 0.0513 | 0.0482 | 0.0545 | 13.51 | 12.67 | 14.36 | 
| Former (i=342) | 0.0645 | 0.0574 | 0.0681 | 10.74 | 10.18 | 12.07 | 
| Current (i=535) | 0.0646 | 0.0603 | 0.0684 | 10.72 | 10.13 | 11.49 | 
Models were adjusted for all covariates (age at exposure, sex, BMI, and smoking history) from the main model with the exception of the stratified variable
The 75th percentile for the log initial PBB measurement was 1.046
The 75th percentile for Body mass index was 28.3