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. Author manuscript; available in PMC: 2024 Feb 1.
Published in final edited form as: Nat Chem Biol. 2022 Oct 10;19(2):141–150. doi: 10.1038/s41589-022-01148-7

Extended Data Fig. 1 |. Metabolic changes with 5 mM serotonin treatment in C. elegans.

Extended Data Fig. 1 |

a, ESI+ ion chromatograms for melatonin synthetic standard and WT C. elegans endo-metabolome extracts. Melatonin was only detected in WT treated with an unphysiologically high concentration (5 mM) of serotonin but was not detected in untreated WT animals. b, Relative abundances of known serotonin metabolites in exo- and endo-metabolome samples of WT treated with 5 mM serotonin. c, Abundances of N-acyl-glycoglycerophosphoethanolamines (GLEAs) in endo-metabolomes of WT treated with 5 mM serotonin. 15 ≤ m ≤ 19, 26 ≤ n ≤ 30, x = 0 or 1. d, Structures of indole-derived MOGLs whose abundances were decreased in WT treated with 5 mM serotonin. Data in b and c represent 3 biologically independent experiments and bars indicate mean ± s.d., p-values calculated via unpaired, two-tailed t-test with Welch correction.