Table 3:
Electrophysiological properties of WT and SOD1 GlyT2-GFP+ interneurons in ventral RC region.
| WT (Mean ± SD) | SOD (Mean ± SD) | p | g (95% CI low, high) | |
| N = 8 | N = 13 | |||
| PIC Onset (mV) | −51.3 (± 5.7) | −45.6 (± 5.5) | 0.036 | 0.971 (−0.058, 1.768) |
| PIC Peak (mV) | −36.8 (± 7.5) | −30.8 (± 4.7) | 0.034 | 0.989 (0.026, 1.919) |
| PIC Amplitude (pA) | 77 (± 44) | 115 (± 71) | 0.218K | 0.579 (−0.299, 1.210) |
| I-ON (pA) | −66 (± 110) | −18 (± 51) | 0.096K | 0.582 (−0.276, 1.398) |
| I-OFF (pA) | −32 (± 58) | 7 (± 54) | 0.060K | 0.671 (−0.293, 1.467) |
| Δ I (pA) | 36 (± 55) | 25 (± 25) | 0.717K | −0.280 (−1.354, 0.679) |
| Threshold on ramp (mV) | −42.4 (± 4.0) | −38.0 (± 6.1) | 0.070K | 0.775 (−0.035, 1.393) |
| Threshold on step (mV) | −47.0 (± 3.1) | −44.1 (± 5.6) | 0.261K | 0.580 (−0.396, 1.150) |
| AHP amplitude (mV) | 11.6 (± 3.9) | 11.4 (± 3.5) | 0.921 | −0.044 (−0.958, 0.904) |
| AHP duration (s) | 0.39 (± 0.19) | 0.36 (± 0.18) | 0.711 | −0.162 (−1.163, 0.676) |
| AHP tau (s−1) | 0.117 (± 0.14) | 0.109 (± 0.07) | 0.346K | −0.078 (−1.329, 0.935) |
| Morphology of Patched interneurons in RC region | ||||
| N = 8 | N = 13 | |||
| Soma | ||||
| Soma Surface Area (μm2) | 589 (± 167) | 700 (± 285) | 0.334 | 0.428 (−0.402, 1.180) |
| Soma Volume (μm3) | 1326 (± 553) | 1841 (± 1150) | 0.253 | 0.508 (−0.294, 1.138) |
| Primary Neurites | ||||
| Total Neurite Length (μm) | 76 (± 24) | 118 (± 50) | 0.044 | 0.931 (0.079, 1.623) |
| Average Neurite Length (μm) | 26 (± 8) | 35 (± 14) | 0.161 K | 0.710 (−0.082, 1.456) |
| Total Neurite Surface Area (μm2) | 408 (± 162) | 681 (± 237) | 0.010K | 1.234 (0.182, 2.320) |
| Average Neurite Surface Area (μm2) | 137 (± 41) | 206 (± 77) | 0.025 K | 1.002 (0.199, 1.708) |
| Total Neurite Volume (μm3) | 196 (± 110) | 391 (± 179) | 0.013K | 1.191 (0.279, 2.049) |
| Average Neurite Volume (μm3) | 65 (± 27) | 120 (± 59) | 0.016 K | 1.060 (0.320, 1.753) |
| Morphology of Unpatched interneurons in RC region | ||||
| N = 188 | N = 225 | |||
| Soma Surface Area (μm2) | 464 (± 180) | 362 (± 168) | 0.106 LM | |
| Soma Volume (μm3) | 515 (± 247) | 358 (± 215) | 0.040 LM | |
K
Indicates Kruskal-Wallis Test for nonparametric distributions
LM
Indicates linear mixed effects model; all others were ANOVA analysis.
Values of g are determined using Hedge’s statistic to calculate effect size and include the 95% confidence interval of the effect size