Table I.
List of genome-wide T. cruzi peptides selected based on occurrence and predicted binding affinity to MHC-I
| Peptide sequence | Name | Predicted allele | Gene ID | Predicted IC50 (nM) | Occurrence score | Gene/gene family |
|---|---|---|---|---|---|---|
| RMMCNISVPI | G1 | H-2-Db | TcCLB.506217.20 | 21.9 | 144 | Beta galactofuranosyl glycosyltransferase |
| RVYGWSGRL | G2 | H-2-Kb | TcCLB.506217.20 | 75.7 | 181 | Beta galactofuranosyl glycosyltransferase |
| SSYIYYNSWL | G3 | H-2-Kb | TcCLB.509949.9 | 6.7 | 180 | DGF |
| FSIQNSSWI | G4 | H-2-Db | TcCLB.504237.10 | 7.3 | 142 | DGF |
| FALLNNTML | G5 | H-2-Db | TcCLB.507821.70 | 7.8 | 119 | DGF |
| FSVTNVSVV | G6 | H-2-Db | TcCLB.508517.9 | 14.9 | 1315 | DGF |
| VALPYFLSV | G7 | H-2-Kb | TcCLB.510499.10 | 15.3 | 1268 | DGF |
| YAVAFYSTV | G8 | H-2-Kb | TcCLB.416809.10 | 29.8 | 2631 | DGF |
| VQYFCMAAV | G9 | H-2-Kb | TcCLB.509427.30 | 77.5 | 995 | DGF |
| VAFYSTVSL | G10 | H-2-Kb | TcCLB.416809.10 | 49.4 | 945 | DGF |
| AMLSNATWV | G11 | H-2-Db | TcCLB.503475.10 | 47.6 | 860 | DGF |
| HALVNMTNV | G12 | H-2-Db | TcCLB.418113.9 | 15.8 | 832 | DGF |
| YAILNANYL | G13 | H-2-Db | TcCLB.506169.10 | 2.3 | 104 | Glycine dehydrogenase [decarboxylating] |
| VGAGYYTAL | G14 | H-2-Kb | TcCLB.508009.10 | 13 | 144 | GP63 |
| VSMLLLLGL | G15 | H-2-Kb | TcCLB.504755.10 | 61.8 | 105 | GP63 |
| SVLAYFTLL | G16 | H-2-Kb | TcCLB.510547.46 | 7 | 148 | Hypothetical protein |
| VSYALKHPI | G17 | H-2-Kb | TcCLB.505935.10 | 38.7 | 114 | Hypothetical protein |
| TVALFVASL | G18 | H-2-Kb | TcCLB.508293.17 | 40.2 | 123 | Hypothetical protein |
| VLLPFTGXL | G19 | H-2-Kb | TcCLB.510547.46 | 63.8 | 142 | Hypothetical protein |
| FSVGNVTLV | G20 | H-2-Db | TcCLB.507691.10 | 72.9 | 156 | Hypothetical protein |
| IVFDGVSSL | G21 | H-2-Kb | TcCLB.508023.12 | 98.2 | 107 | Hypothetical protein |
| YMFLNWHELL | G22 | H-2-Db | TcCLB.511183.26 | 35.1 | 108 | MASP |
| VSALAYTTL | G23 | H-2-Kb | TcCLB.504669.50 | 30.9 | 188 | Mucin TcMUCI |
| SALAYTAV | G24 | H-2-Kb | TcCLB.511099.23 | 55 | 104 | Mucin TcMUCI |
| SSAWVCAPL | G25 | H-2-Kb | TcCLB.506909.20 | 99.9 | 1987 | Mucin TcMUCI |
| SSYLLYQLL | G26 | H-2-Kb | TcCLB.506823.80 | 5.5 | 105 | RHS |
| FAFLNGSFV | G27 | H-2-Db | TcCLB.507497.20 | 6.9 | 167 | RHS |
| VAMVFXGSV | G28 | H-2-Kb | TcCLB.506803.30 | 14 | 176 | RHS |
| AAYFNGWEEL | G29 | H-2-Db | TcCLB.503661.20 | 66.9 | 250 | RHS |
| AVSAFLNEDFL | G30 | H-2-Db | TcCLB.511549.10 | 74.5 | 150 | RHS |
| AGSYLLYQLL | G31 | H-2-Kb | TcCLB.470827.10 | 86.7 | 463 | RHS |
| FIFRNTVYM | G32 | H-2-Db | TcCLB.507153.40 | 29.8 | 172 | Tryptophanyl-tRNA synthetase |
| RVPLFVAHL | G33 | H-2-Kb | TcCLB.504779.10 | 22.2 | 162 | UDP-Gal or UDP-GlcNAc-dependent glycosyltransferase |