. Author manuscript; available in PMC: 2024 Feb 1.

Published in final edited form as: J Bone Miner Res. 2022 Dec 28;38(2):261–277. doi: 10.1002/jbmr.4757

Table 4.

Final regression models of sample averaged nanomechanical organized by patient characteristics and sample averaged compositional properties. Values are shown as parameter coefficients with standard error in parentheses. Regression coefficients were determined from backward stepwise regressions using the minimum Akaike information criterion (AICc). Abbreviations: P1NP = amino-terminal propeptide of type 1 collagen; M:M = Mineral to matrix ratio; MMC = Mineral maturity/crystallinity; C:P = Carbonate to phosphate ratio.

	Cortical Bone		Trabecular Bone
	Modulus (GPa)	Hardness (GPa)	Modulus (GPa)	Hardness (GPa)
Race (black)	-	−0.03 (0.01)	−1 (0.2)	−0.03 (0.01)
HbA1c (%)	0.26 (0.12)	0.016 (0.0049)	-	-
P1NP (ng/mL)	-	-	0.03 (0.01)	-
M:M (unitless)	-	-	5.7 (1.6)	0.14 (0.085)
MMC (unitless)	1634 (536.2)	-	-	-
C:P (unitless)	-	-	24 (3.9)	0.64 (0.21)
Adjusted R²	0.353	0.287	0.631	0.266