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. 2023 Feb 3;14(2):80. doi: 10.1038/s41419-023-05628-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A GSEA analysis showed the different gene set between TMEM105-high and TMEM105-low of breast cancer patients in the TCGA dataset. NES normalized enrichment score, FDR false discovery rate. B Expression of TMEM105 was determined by qRT-PCR in MCF10A, MCF-7, T47D, MDA-MB-231, and BT549 cells. C Effects of overexpression or knockdown of TMEM105 in breast cancer cells as shown by qRT-PCR. ECAR level (D), glucose consumption (E), and lactate production (F) were determined after TMEM105 overexpression in MCF-7 and T47D cells. ECAR level (G), glucose consumption (H), and lactate production (I) were measured after the knockdown of TMEM105 in MDA-MB-231 and BT549 cells. 2-DG 2-deoxyglucose. **p < 0.01.