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. 2023 Feb 3;14(2):80. doi: 10.1038/s41419-023-05628-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — A Expression of glycolysis-related genes in TMEM105-overexpressing MCF-7 and T47D cells as well as in TMEM105-knockdown MDA-MB-231 and BT549 cells. B Western blot analysis of PGK1, PKM2, and LDHA in TMEM105-overexpressing MCF-7 and T47D cells as well as in TMEM105-knockdown MDA-MB-231 and BT549 cells. C Representative immunohistochemical staining for LDHA expression in breast cancer tissues without or with BCLM. Spearman’s correlation between TMEM105 and LDHA expression in breast cancer tissues of the patients in the Hebei dataset (n = 68). Scale bars, 50 μm. D The correlation between TMEM105 and LDHA expression determined by qRT-PCR in breast cancer tissues in the Hebei dataset. ECAR level (E), glucose consumption (F), and lactate production (G) were determined in TMEM105-overexpressing MCF-7 cells. ECAR level (H), glucose consumption (I), and lactate production (J) were determined in TMEM105-knockdown MDA-MB-231 cells. *p < 0.05, **p < 0.01.