Table 1.
Univariate and multivariate Cox regression analyses of overall survival in breast cancer patients.
| Characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| Hazard ratio (95% CI) | p value | Hazard ratio (95% CI) | p value | |
| Pathologic stage (II + III + IV versus I) | 2.210 (1.313–3.721) | 0.003 | 1.925 (1.047–3.542) | 0.035 |
| Tumor size (T3 + T4 versus T1 + T2) | 1.608 (1.110–2.329) | 0.012 | 1.332 (0.827–2.147) | 0.238 |
| Lymph node metastasis (N2-3 versus N0-1) | 2.163 (1.472–3.180) | <0.001 | 1.992 (1.211–3.277) | 0.007 |
| M stage (M1 versus M0) | 4.254 (2.468–7.334) | <0.001 | 2.114 (0.970–4.607) | 0.060 |
| Race (White versus Asian) | 1.325 (0.420–4.186) | 0.631 | ||
| Race (Black + African American versus Asian) | 1.525 (0.463–5.024) | 0.488 | ||
| Histological type (ILC versus IDC) | 0.827 (0.526–1.299) | 0.410 | ||
| ER status (Positive versus Negative) | 0.725 (0.505–1.041) | 0.082 | 0.623 (0.310–1.250) | 0.183 |
| PR status (Positive versus Negative) | 0.733 (0.525–1.025) | 0.070 | 0.780 (0.413–1.474) | 0.445 |
| Age (>60 versus ≤60) | 2.020 (1.465–2.784) | <0.001 | 2.174 (1.475–3.205) | <0.001 |
| PAM50 (LumB versus LumA) | 1.663 (1.088–2.541) | 0.019 | 1.080 (0.653–1.787) | 0.765 |
| PAM50 (Her2 versus LumA) | 2.261 (1.325–3.859) | 0.003 | 1.287 (0.585–2.831) | 0.530 |
| PAM50 (Basal versus LumA) | 1.285 (0.833–1.981) | 0.257 | 0.845 (0.394–1.809) | 0.664 |
| TMEM105 expression (high versus low) | 1.575 (1.138–2.180) | 0.006 | 1.483 (1.005–2.186) | 0.047 |