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. Author manuscript; available in PMC: 2024 Feb 1.
Published in final edited form as: Neuron. 2023 Jan 12;111(3):302–327. doi: 10.1016/j.neuron.2022.12.022

Figure 3: THC inactivation by CYP2C and biased signaling at CB1R.

Figure 3:

A] THC is metabolized to 11-OH-THC by the P450 enzyme CYP2C9. Fatty acid binding proteins (FABP) assist THC in being metabolized. B] THC activates CB1R that couple to Gαi proteins that inhibit adenylyl cyclase, Gbg proteins that regulate ion channels and b-arrestin that regulates kinase signaling. Different agonist will often preferentially modulate one of these signaling pathway. FABPassist THC in activating CB1R.