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. Author manuscript; available in PMC: 2024 Feb 1.
Published in final edited form as: Neuron. 2023 Jan 12;111(3):302–327. doi: 10.1016/j.neuron.2022.12.022

Figure 8: Molecular targets modulated by CBD.

Figure 8:

A] CBD is a negative allosteric modulator of CB1R that is endogenously activated by 2-AG and AEA, an antagonist of GPR55 that is endogenously activated by lysophosphatidyl inositol (LPI) and activate 5HT1A that is endogenously activated by serotonin. B] CBD is an agonist at TRPV1 that is activated by eicosanoids (Eico) and changes in H+, a positive allosteric modulator of GABAAR that is activated by GABA and endogenously allosterically modulated by 2-AG, and a blocker of ENT-1 transporters that carry adenosine.