Table 4.
Reaction conditions and yields for substituted 1-Phenylcyclopropane carboxylic acid derivatives (3a–3g).
S.No | SM | Product | Time | Yield (%) | Amide (side product) |
---|---|---|---|---|---|
1 | 2a | 3a | 3 h | 80% | 8% |
2 | 2b | 3b | 2 h | 85% | 5% |
3 | 2c | 3c | 2.5 h | 88% | 3% |
4 | 2d | 3d | 3 h | 77% | 14% |
5 | 2e | 3e | 3.5 h | 75% | 10% |
6 | 2f | 3f | 4 h | 72% | 10% |
7 | 2g | 3g | 4 h | 64% | 15% |
*All reactions were carried out on a 10 mg scale. The reaction was monitored by TLC and LCMS. 1-Phenylcyclopropane acetonitrile (1.0 eq), 35% Hydrochloric acid (5.0 eq), H2O (5 vol), 110 °C.