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. 2023 Jan 24;9(2):e13111. doi: 10.1016/j.heliyon.2023.e13111

Table 4.

Reaction conditions and yields for substituted 1-Phenylcyclopropane carboxylic acid derivatives (3a–3g).

S.No SM Product Time Yield (%) Amide (side product)
1 2a 3a 3 h 80% 8%
2 2b 3b 2 h 85% 5%
3 2c 3c 2.5 h 88% 3%
4 2d 3d 3 h 77% 14%
5 2e 3e 3.5 h 75% 10%
6 2f 3f 4 h 72% 10%
7 2g 3g 4 h 64% 15%

*All reactions were carried out on a 10 mg scale. The reaction was monitored by TLC and LCMS. 1-Phenylcyclopropane acetonitrile (1.0 eq), 35% Hydrochloric acid (5.0 eq), H2O (5 vol), 110 °C.