Table 5.
Synthesis of Phenoxy acetyl derivatives with different bases.
S.No | SM | Product | Temperature (°C) | Base | Time (h) | Yield (%) |
---|---|---|---|---|---|---|
1 | 4a | 5a | 60 | Na2CO3 | 12 | 61 |
2 | 4a | 5a | 60 | K2CO3 | 12 | 75 |
3 | 4a | 5a | 60 | Cs2CO3 | 12 | 55 |
4 | 4b | 5b | 60 | Na2CO3 | 12 | 43 |
5 | 4b | 5b | 60 | K2CO3 | 12 | 78 |
6 | 4b | 5b | 60 | Cs2CO3 | 12 | 61 |
7 | 4c | 5c | 60 | Na2CO3 | 12 | 39 |
8 | 4c | 5c | 60 | K2CO3 | 12 | 70 |
9 | 4c | 5c | 60 | Cs2CO3 | 12 | 45 |
10 | 6 | 7 | 60 | Na2CO3 | 12 | 35 |
11 | 6 | 7 | 60 | K2CO3 | 12 | 41 |
12 | 6 | 7 | 60 | Cs2CO3 | 12 | 49 |
13 | 6 | 7 | 80 | Cs2CO3 | 16 | 79 |
*All reactions were carried out on a 10 mg scale. The reaction was monitored by TLC and LCMS. Amino phenol (1.0 eq), Methyl 2-chloroacetate (2.0 eq), base (3.0 eq).