. 2023 Jan 24;9(2):e13111. doi: 10.1016/j.heliyon.2023.e13111

Table 6.

Reaction conditions for 1-Phenylcyclopropane carboxamide derivative (8a).

S.No	Reagent	Base	Solvent	Time (h)	Yield (%)
1	EDC	Et₃N	THF	20	41
2	EDC	Et₃N	DMF	18	45
3	EDC	DIPEA	THF	16	62
4	EDC	DIPEA	DMF	12	65
5	HATU	Et₃N	THF	20	46
6	HATU	Et₃N	DMF	18	49
7	HATU	DIPEA	THF	16	75
8	HATU	DIPEA	DMF	12	85
9	HBTU	Et₃N	THF	20	48
10	HBTU	Et₃N	DMF	18	51
11	HBTU	DIPEA	THF	16	68
12	HBTU	DIPEA	DMF	12	70
13	T₃P	Et₃N	THF	20	47
14	T₃P	Et₃N	DMF	18	49
15	T₃P	DIPEA	THF	16	64
16	T₃P	DIPEA	DMF	12	68

*All reactions were carried out on a 10 mg scale. The reaction was monitored by TLC and LCMS. Acid (1.0 eq), Amine (1.0 eq), coupling reagent (1.5 eq), base (3.0 eq), solvent (5 vol). EDC (1-Ethyl-3-(3-dimethylaminopropyl)carbodiimide). HATU (1-[Bis(dimethylamino) methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxide hexafluoro phosphate). HBTU (3-[Bis(dimethylamino)methyliumyl]-3H-benzotriazol-1-oxide hexafluorophosphate). T₃P (Propanephosphonic acid anhydride).