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. 2023 Jan 24;9(2):e13111. doi: 10.1016/j.heliyon.2023.e13111

Table 7.

Synthesis of 1-Phenylcyclopropane carboxamide derivatives (8a–8t).

S.No Acid Amine Product Yield (%)
1 3a 7 8a 85
2 3a 5a 8b 72
3 3a 5b 8c 84
4 3a 5c 8d 81
5 3b 7 8e 78
6 3b 5a 8f 76
7 3b 5b 8g 81
8 3c 7 8h 83
9 3c 5a 8i 76
10 3d 5a 8j 79
11 3d 5b 8k 71
12 3e 7 8l 79
13 3e 5a 8m 84
14 3e 5b 8n 88
15 3e 5c 8o 91
16 3f 7 8p 72
17 3f 5a 8q 80
18 3f 5b 8r 83
19 3g 5a 8s 73
20 3g 5b 8t 88

*All reactions were carried out on a 10 mg scale. The reaction was monitored by TLC and LCMS. Acid (1.0 eq), Amine (1.0 eq), HATU (1.5 eq), DIPEA (3.0 eq), DMF (5 vol).