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. Author manuscript; available in PMC: 2024 Feb 2.
Published in final edited form as: Mol Cell. 2023 Jan 9:S1097-2765(22)01203-5. doi: 10.1016/j.molcel.2022.12.024

Figure 3 |. Waves of cyclins and DNA replication proteins in human and budding yeast during cell cycle progression.

Figure 3 |

Human and budding yeast replication proteins ORC1/Orc1 and CDT1/Cdt1 (in blue) and CDC6/Cdc6 (in pink) proteins levels as well as Mcm2-7/Mcm2-7 single hexamer (in lime green) and Mcm2-7/Mcm2-7 double hexamer (in dark green) loading levels are shown as lines. Pre-RC assembly corresponds to Mcm2-7/Mcm2-7 double hexamer formation. Cyclin-dependent kinases activities are shown as solid areas with Cyclin E-CDK2 in human and Cln-Cdc28 in budding yeast are shown in yellow, while Cyclin A-CDK2 in human and Clb5-Cdc28 and Clb6-Cdc28 in budding yeast are shown in dark blue. G1, S, G2, M phases in cell cycle are indicated.