Fig. 1.

¹H MRSI EPSI sequence positioning and processing output. (A-B): Reconstructed sagittal and coronal T1-weighted MRI images of a control subject, superimposed with the 280 × 280 × 135 mm³ field-of-view (dotted green lines) and the 280 × 280 × 100 mm³ excitation slab (solid orange lines) partitioned into 32 slices, corresponding to the MRSI-resolution of 0.08 cm³ after interpolation. (C): Six reconstructed axial T1-weighted MRI images in accordance with the numbered slices (blue arrows and bars) designated in (A) and (B). (D-F): Tissue segmentation maps of CSF, GM, and WM, derived from the T1-weighted MRI in (C) and down-sampled to the MRSI-resolution. (G): The water reference image, used to support image registration, spatial transformations, and signal normalization procedures. (H-L): Metabolite maps and an accompanying quality map (M), in which red indicates voxels with metabolite linewidth <12 Hz and signal <3 standard deviations from the mean. Voxels within regions that are colored dark blue, cyan, and green on the quality map were excluded from the analysis. Abbreviations: MPRAGE, Magnetization Prepared Rapid Gradient Echo; CSF, cerebrospinal fluid; GM, gray matter; WM, white matter; Cho, choline; Cr, creatine; Glx, glutamate plus glutamine; mI, myo-inositol; NAA, N-acetyl-aspartate. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)