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. 2022 Nov 17;396(3):485–498. doi: 10.1007/s00210-022-02322-3

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — The effect of rivastigmine and/or leflunomide on hippocampal acetylcholinesterase (AChE) activity in AlCl₃-induced AD in rats. A Treatment protocol, B prophylaxis protocol. Data are presented as mean ± SD (n = 6) and tested by one-way ANOVA followed by the Tukey post hoc test using GraphPad Prism (v.8). Riva, rivastigmine; Lef, leflunomide. Significant changes are reported at p < 0.05. *Significance relative to the control group. #Significance relative to the AlCl₃ group. •Significance relative to the rivastigmine group. ^$Significance relative to the leflunomide group