Table 1.
Plasma phloroglucinol (1,3,5-trihydroxybenzene) PK parameters
| Treatment | 1,3,5-Trihydroxybenzene | ||||||
|---|---|---|---|---|---|---|---|
| C0 (ng/mL) | AUC0–t (ng/mL x h) |
AUC0–∞ (ng/mL × h) | t1/2 (h) | MRT (h) | Cl/BW (L/h × kg) | VD/BW (L/kg) | |
| Test A—i.v. 40 mg | 1607.20 ± 375.23 (23.35) | 385.41 ± 104.34 (27.07) | 398.79 ± 104.51 (26.21) | 1.28 ± 0.18 (14.23) | 1.53 ± 0.22 (14.35) | 0.22 ± 0.11 (49.69) | 0.39 ± 0.16 (41.01) |
| Cmax (ng/mL) | Tmax (h) | AUC0–t (ng/mL × h) | AUC0–∞ (ng/mL × h) | t1/2 (h) | MRT (h) | Cl/F/BW (L/h × kg) | VD/F/BW (L/kg) | |
|---|---|---|---|---|---|---|---|---|
| Test B—p.o. 160 mg | 384.25 ± 125.14 (32.57) | 0.75 ± 0.37 (48.96) | 631.65 ± 146.74 (23.23) | 644.75 ± 146.86 (22.78) | 1.31 ± 0.17 (12.63) | 1.77 ± 0.25 (13.95) | 3.70 ± 0.67 (18.15) | 7.01 ± 1.62 (23.10) |
Data are presented as mean ± SD (CV%)
N = 16