Fig. 2.

Ai Prediction function by restricted cubic splines for the continuous relationship between QRS width progression and heartrate. Restricted cubic splines were used to define cut-offs for patients at risk. Datasets were stratified according to the presence or absence of QRS width progression. Aii Cox proportional hazard model for patients with a heart rate > 83/min and QRS width progression stepwise adjusted for age and sex (model 1), IVSd (model 2) and additional guideline directed medical therapy (model 3). Bi, Bii As in A except for NTproBNP. C Interaction analysis for heartrate and NTproBNP risk groups by an age- and sex-adjusted Cox proportional hazard model for QRS width progression