Table 3.

Detailed characteristics of patients with positive CMV histopathology on colonic biopsies

Biologic	Sex	Prior history of CMVC	Age at biologic initiation	Mayo endoscopic subscore prior to biologic initiation	Mayo endoscopic subscore at time of biopsies for CMV	Days from biologic initiation to CMV biopsies	Colon CMV histopathology	Corticosteroids at the time of colonic biopsies for CMV	CMV biopsies taken during a hospitalization	Received antiviral therapy for CMVC	Colectomy within 30 days of CMVC	Death within 30 days of CMVC
IFX	F	No	78	3	3	9	Numerous CMV inclusions are present.	Yes	Yes	Yes	No	No
ADA	M	No	32	2	2	382	Immunohistochemical stain for CMV shows scattered positive cells.	Yes	No	Yes	No	No
IFX	M	No	78	3	3	7	Viral cytopathic effect consistent with cytomegalovirus infection (H&E stain).	Yes	Yes	Yes	Yes	No†
IFX	M	No	24	3	3	6	Numerous enlarged cells with viral inclusions are identified. These cells are positive for CMV on immunochemistry.	Yes	Yes	Yes	No	No
IFX	M	No	32	3	3	17	CMV positive on immunohistochemical staining	Yes	Yes	Yes	No	No
ADA	F	No	19	3	2	55	Rare endothelial cells immunohisto-chemically positive for CMV	Yes	Yes	No	No	No

^†Death did occur 34 days after CMV colitis diagnosis (due to post-operative complications after colectomy).

Abbreviations: CMVC = cytomegalovirus colitis, ADA = adalimumab, IFX = infliximab, F = female, M = male