The high-fat diet with EV injection (HVM) group had significant decreases in expression of pro-inflammatory markers NFκB, p-NFκB, pro-IL1ß, and CD11c compared to the control group. Upper and lower borders of box represent upper and lower quartiles, middle horizontal line represents median, upper and lower whiskers represent maximum and minimum values of non-outliers. *p<0.05 as determined by Wilcoxon rank-sum test.