Table 1:

Inflammatory protein expression in ischemic myocardium of EV-treated swine.

Protein	Median (IQR)	P Value
Pro-Inflammatory
NFκB	0.80 (0.70–0.84)	0.002
P-NFκB	0.75 (0.72–0.79)	0.029
Pro-IL1β	0.83 (0.67–0.86)	0.020
CD11c	0.49 (0.42–0.57)	0.001
HLA-DRA	0.78 (0.71–1.03)	0.66
IL-6	0.79 (0.61–0.94)	0.28
TNF-α	0.85 (0.79–0.95)	0.35
TLR4	1.17 (0.86–1.26)	0.49
TLR2	0.87 (0.67–0.89)	0.18
iNOS	1.02 (0.97–1.13)	0.57
CD40	0.79 (0.69–1.0)	0.18
Anti-Inflammatory
IL-10	1.20 (1.18–1.46)	0.020
CD163	1.59 (1.19–1.83)	0.043
Arginase	1.10 (0.64–1.32)	0.85
NFκβ Regulators
IKB-α	0.95 (0.86–1.00)	0.41
p-IKB-α	0.92 (0.81–1.02)	0.85

Statistics presented as median fold change (interquartile range) in extracellular vesicle (EV) treated swine (n=8) compared to average control (n=6). P values calculated using Wilcoxon rank-sum test.