Table 1.

Optimized Suzuki‐Miyaura coupling reaction conditions.

Entry	Base	Solvent	Pd (mol%)	Time (min)	Temp (°C)	Yield (%)a
1	K2CO3	EtOH/H2O(1:1)	0	180	80	0
2	K2CO3	EtOH/H2O(1:1)	0.3	30	80	98
3	K2CO3	EtOH/H2O(1:1)	0.3	15	80	98
4	K2CO3	EtOH/H2O(1:1)	0.3	90	40	65
5	K2CO3	EtOH/H2O(1:1)	0.3	90	r.t	50
6	K2CO3	EtOH/H2O(1:1)	0.3	15	60	98
7	K2CO3	H2O	0.3	30	60	50
8	K2CO3	EtOH	0.3	30	60	50
9	K2CO3	MeCN	0.3	30	60	60
10	K2CO3	THF	0.3	30	60	45
11	K2CO3	DMSO	0.3	30	60	68
12	K2CO3	DMF	0.3	30	60	70
13	K2CO3	EtOH/H2O(1:1)	0.2	15	60	77
14	K2CO3	EtOH/H2O(1:1)	0.15	15	60	56
15	No base	EtOH/H2O(1:1)	0.3	30	60	4

Reaction condition: phenylboronic acid (0.6 mmol), base (0.4 mmol), Iodobenzene (0.5 mmol), solvent (2 mL), nanocatalyst (0.3 mol%).

^aIsolated yield.