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. 2023 Feb 3;14:583. doi: 10.1038/s41467-023-36311-8

Fig. 1. Overview of this study.

Fig. 1

a RNA-seq and matched genotype data were collected from the GTEx, ROS/MAP, and PsychENCODE cohorts as reference panels. We then performed 3′aQTL analysis and built 3′aTWAS models to predict the APA usage of target genes with cis-SNPs in the reference panels. b We performed 3′aTWAS analysis to nominate susceptibility genes in brain disorders using GWAS summary statistics and 3′aTWAS models in each reference panel. c APA-linked susceptibility genes in brain disorders identified by 3′aTWAS, which confirmed two previously validated risk APA genes (SNCA and DDHD2). This schematic was created with BioRender.