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. 2023 Jan 13;55(1):215–227. doi: 10.1038/s12276-023-00925-1

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© The Author(s) 2023, corrected publication 2023

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Fig. 1 — a Briefly, the mice were fed CPZ for 2 weeks under a normal light/night cycle. Thereafter, treatments were initiated at the beginning of Week 3 in the presence of CPZ. Both the Ctrl group and the vehicle (untreated CPZ) were kept on a normal light/night cycle. The melatonin (80 mg/kg) and Luzindole (30 mg/kg) groups received these drugs by IP daily at 9 AM and 6 PM, respectively, and were maintained on a normal light/night cycle. Light was set ON or OFF for 3 days in the constant light or constant darkness groups, respectively, followed by one day of normal light/night. This cycle was repeated 5 times. BrdU in drinking water was started at the beginning of the manipulations in Week 3. b Brain levels of melatonin and (c) cortisol were analyzed using ELISA at the end of the study (n = 5 mice/group). Significance is indicated by ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗∗p < 0.0001.