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. 2023 Jan 13;55(1):215–227. doi: 10.1038/s12276-023-00925-1

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© The Author(s) 2023, corrected publication 2023

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Fig. 3 — a Fluorescent staining of newly generated BrdU+ cells. Olig2 is a marker of the oligodendroglial lineage. APC is a marker of mature oligodendrocytes. DAPI staining of the nucleus. Left panel, the blue arrow shows immature OLs, and the yellow arrow shows mature OLs. b Quantification of the oligodendroglia lineage (BrdU + /Olig2+ cells), which includes both immature and mature OLs. c Quantification of immature OLs (OPCs; BrdU + /Olig2 + /APC- cells). d Quantification of mature OLs (BrdU + /Olig2 + /APC + cells). e Costaining of the apoptosis marker Caspase-3 and the oligodendrocyte marker APC. Right panel: The arrow indicates Caspase-3 colocalization with APC. f Quantification of the mean number of Caspase-3 + /APC + cells. All quantifications were performed in the middle corpus callosum along the rostrocaudal axis. (n = 5 mice/group; 3 slides per mouse). Significance is indicated by ^∗p < 0.05; ^∗∗p < 0.01; and ^∗∗∗p < 0.001. Scale bars, 20 μm.