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Runx2 in OA pathogenesis. A diagram showing the upstream and downstream of Runx2 in OA pathogenesis. Runt-related transcription factor 2 (Runx2) is upregulated by activation of Wnt/β-catenin, NF-κB, Hedgehog, HIF-2α signaling, and by suppression of TGF-β/Smads and focal adhesion signaling in OA chondrocytes. miR-204 and miR-211 inhibit the expression of Runx2 protein in articular chondrocytes in vivo. Red arrow: upregulated expression. Yellow arrow: downregulated expression
