Table 2.
Estimated total annual medical costs and OOP costs (95% CI) among surviving individuals with SCD and matched controls, by age group and sex
| Age (yr) | Individuals with SCD | Matched Controls | SCD-attributable Costs∗ | P value† |
|---|---|---|---|---|
| Total medical costs, $ | ||||
| Females, yr | ||||
| 0-5 | 26 835 (16 400-37 271) | 1 722 (1 405-2 040) | 25 113 (3 661-46 565) | .01 |
| 6-12 | 28 575 (20 001-37 149) | 2 006 (1 678-2 334) | 26 569 (10 521-42 617) | <.01 |
| 13-18 | 37 283 (34 637-39 930) | 2 316 (1 986-2 647) | 34 967 (30 039-39 895) | <.01 |
| 19-24 | 41 020 (36 422-45 618) | 2 631 (2 291-2 971) | 38 389 (30 020-46 758) | <.01 |
| 25-34 | 34 105 (30 478-37 732) | 3 162 (2 789-3 536) | 30 943 (24 600-37 286) | <.01 |
| 35-54 | 36 574 (34 132-39 017) | 4 520 (3 956-5 084) | 32 054 (28 119-35 989) | <.01 |
| 55-64 | 47 780 (37 100-58 460) | 6 230 (5 148-7 313) | 41 550 (26 767-56 333) | <.01 |
| Males, yr | ||||
| 0-5 | 29 327 (20 927-37 681) | 1 546 (1 166-1 926) | 27 781 (10 327-45 235) | <.01 |
| 6-12 | 31 504 (25 376-37 632) | 1 767 (1 368-2 167) | 29 737 (18 040-41 434) | <.01 |
| 13-18 | 40 306 (36 909-43 703) | 2 038 (1 629-2 447) | 38 268 (32 216-44 320) | <.01 |
| 19-24 | 44 228 (37 015-51 442) | 2 338 (1 910-2 767) | 41 890 (30 415-53 365) | <.01 |
| 25-34 | 36 691 (34 288-39 093) | 2 774 (2 311-3 237) | 33 917 (30 367-37 467) | <.01 |
| 35-54 | 39 968 (36 783-43 154) | 4 013 (3 352-4 675) | 35 955 (31 461-40 449) | <.01 |
| 55-64 | 50 981 (37 542-64 420) | 5 439 (4 419-6 459) | 45 542 (29 305-61 779) | <.01 |
| OOP COSTS, $ | ||||
| Females, yr | ||||
| 0-5 | 1 232 (1 123-1 341) | 195 (167-223) | 1 037 (813-1 261) | <.01 |
| 6-12 | 1 152 (975-1 328) | 224 (197-252) | 928 (597-1 259) | <.01 |
| 13-18 | 1 236 (1 129-1 342) | 257 (229-284) | 979 (781-1 177) | <.01 |
| 19-24 | 1 379 (1 285-1 473) | 287 (256-318) | 1 092 (920-1 264) | <.01 |
| 25-34 | 1 399 (1 303-1 496) | 349 (313-386) | 1 050 (881-1 219) | <.01 |
| 35-54 | 1 324 (1 261-1 387) | 495 (429-561) | 829 (719-939) | <.01 |
| 55-64 | 1 445 (1 305-1 584) | 673 (539-806) | 772 (556-988) | <.01 |
| Males | ||||
| 0-5 | 1 223 (1 102-1 344) | 192 (149-234) | 1 031 (777-1 285) | <.01 |
| 6-12 | 1 181 (1 025-1 336) | 219 (174-264) | 962 (665-1 259) | <.01 |
| 13-18 | 1 271 (1 184-1 358) | 250 (203-298) | 1 021 (864-1 178) | <.01 |
| 19-24 | 1 399 (1 294-1 504) | 279 (225-332) | 1 120 (949-1 291) | <.01 |
| 25-34 | 1 434 (1 314-1 554) | 333 (277-388) | 1 101 (920-1 282) | <.01 |
| 35-54 | 1 394 (1 301-1 486) | 484 (401-567) | 910 (767-1 053) | <.01 |
| 55-64 | 1 463 (1 310-1 616) | 648 (512-785) | 815 (598-1 032) | <.01 |
All costs are in 2020 USD. Raw costs (not model-estimated) are shown in supplemental Table 1 for comparison.
∗
SCD-attributable costs are the difference between individuals with SCD and matched controls.
†
Two-sample independent t test.