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Schema of the lipid metabolism in malignant lymphoma. Malignant lymphomas have unregulated the negative feedback of LDL receptor (LDLR) and increased LDL uptake. Scavenger receptor class B type I (SR-BI) inhibitor blocks cholesterol efflux to HDL, leading to intracellular over-accumulation of free cholesterol. As a result, apoptosis is induced in malignant lymphoma cells due to cholesterol toxicity.
