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. 2023 Jan 5;4(1):100380. doi: 10.1016/j.xinn.2023.100380

Figure 6.

Figure 6

Exercise resets the circadian clock machinery across aged tissues

(A) Network plots showing the upregulated aging TFs (left) and downregulated aging TFs (right).

(B) Heatmaps showing the expression profiles of overlapped Rev-aging DEGs based on the sc/snRNA-seq and bulk RNA-seq data across different cell types from different tissues. The color key from blue to yellow indicates gene expression levels from low to high.

(C) Bubble plots showing the cell type frequency and tissue frequency (more than 5 tissues and 20 cell types) of upregulated (left) and downregulated (right) rescued DEGs.

(D) Heatmaps showing the expression profiles of circadian rhythm-related Rev-aging DEGs for different cell types across different tissues. The color key from blue to red indicates gene expression levels from low to high.