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. 2023 Feb 3;6(2):e2254313. doi: 10.1001/jamanetworkopen.2022.54313

Figure 2. Effects of Kisspeptin (KP) on Sexual Brain Activity and Behavior During the Short Sexual Videos Task.

Figure 2.

A, Whole-brain analysis showing increased activity in the left anterior cingulate and left middle frontal gyrus and decreased activity in the bilateral parahippocampus by KP administration in response to short sexual videos. Red and yellow areas show relative activation to sexual vs exercise videos (control) during KP administration compared with placebo. Blue and green areas show relative deactivation to sexual vs exercise videos during KP administration compared with placebo. Clusters are corrected for multiple comparisons (z = 2.3; P < .05 for all comparisons; N = 32). L indicates left; R, right. B, Correlation analysis demonstrating that participants with higher baseline sexual desire distress scores showed greater KP-enhanced brain activity in the posterior cingulate cortex in response to short sexual videos compared with exercise videos. In B and C, placebo/KP depicts the 16 participants who received placebo at the first study visit and KP at the second study visit; KP/placebo depicts the 16 participants who received KP at the first study visit and placebo at the second study visit. C, Correlation analysis demonstrating that the more KP enhanced globus pallidus activity, the more sexually “naughty” the participants felt in response to short sexual videos compared with exercise videos.