Table. Participant Clinical and Psychometric Characteristicsa.
| Characteristic | Treatment sequenceb | All participants (N = 32) | |
|---|---|---|---|
| Placebo/kisspeptin (n = 16) | Kisspeptin/placebo (n = 16) | ||
| Age, y | 36.1 (7.8) | 39.7 (9.3) | 37.9 (8.6) |
| Body mass indexc | 24.0 (7.0) | 25.9 (3.0) | 24.9 (5.4) |
| Baseline hormone profile (reference range) | |||
| Kisspeptin, pmol/L | 31.3 (27.0) | 18.1 (7.1) | 24.7 (20.6) |
| Luteinizing hormone (2-12), IU/L | 3.3 (1.4) | 2.9 (1.3) | 3.1 (1.3) |
| Follicle-stimulating hormone (1.7-8), IU/L | 4.2 (3.5) | 3.3 (1.6) | 3.8 (2.7) |
| Testosterone (10-30), nmol/L | 20.0 (7.0) | 16.9 (5.0) | 18.5 (6.2) |
| Sex hormone–binding globulin (15-55), nmol/L | 37.1 (12.3) | 34.5 (11.8) | 35.8 (12.0) |
| Thyroid-stimulating hormone (0.3-4.2), mIU/L | 1.4 (0.4) | 1.5 (0.7) | 1.4 (0.6) |
| Free T4 (9-23), pmol/L | 12.0 (1.0) | 11.3 (2.2) | 11.6 (1.7) |
| Duration of current relationship, y | 6.9 (6.0) | 8.7 (8.9) | 7.8 (7.5) |
| Overall satisfaction with partnerd | 3.3 (1.2) | 3.4 (0.9) | 3.3 (1.0) |
| No. of sexual partners in past year | 1.1 (0.6) | 0.9 (0.5) | 1.0 (0.6) |
| Frequency of sexual intercourse per month | 1.6 (1.1) | 3.1 (3.3) | 2.3 (2.5) |
| Hours viewing pornographic material per week | 0.7 (1.1) | 0.8 (1.3) | 0.8 (1.2) |
| Psychometric assessment | |||
| Behavioral Inhibition System Scalee | 20.9 (3.3) | 20.4 (2.4) | 20.6 (2.8) |
| Behavioral Activation and System Scalef | |||
| Drive | 11.4 (2.2) | 10.9 (2.7) | 11.2 (2.5) |
| Fun | 12.2 (2.4) | 11.6 (1.7) | 11.9 (2.1) |
| Reward | 16.8 (2.1) | 16.4 (2.2) | 16.6 (2.2) |
| Generalized Anxiety Disorder Assessment-7g | 2.1 (1.6) | 1.8 (3.3) | 1.9 (2.6) |
| International Index of Erectile Functionh | |||
| Erectile function | 26.5 (8.2) | 27.1 (9.0) | 26.8 (4.5) |
| Orgasmic function | 6.6 (2.6) | 5.9 (3.2) | 6.2 (2.9) |
| Sexual desire | 3.9 (1.2) | 4.5 (2.4) | 4.2 (1.9) |
| Intercourse satisfaction | 6.9 (2.7) | 6.2 (3.9) | 6.5 (3.3) |
| Overall satisfaction | 4.3 (2.1) | 4.6 (1.6) | 4.4 (1.9) |
| Patient Health Questionnaire-9i | 2.6 (2.7) | 2.3 (2.3) | 2.5 (2.5) |
| Sexual Desire Inventoryj | |||
| Dyadic | 21.7 (7.2) | 25.8 (10.8) | 23.7 (9.3) |
| Solitary | 9.4 (4.7) | 7.2 (3.6) | 8.3 (4.2) |
| Total | 38.6 (12.8) | 40.4 (15.4) | 39.5 (14.0) |
| Sexual Concerns Inventory–Malek | |||
| Desire distress domain | 3.3 (0.9) | 3.2 (0.9) | 3.3 (0.9) |
| Total | 29.3 (7.6) | 29.0 (8.4) | 29.1 (7.9) |
| Subjective Happiness Scalel | 17.5 (5.6) | 18.1 (4.3) | 4.4 (1.2) |
| Sexual Quality of Life–Malem | 31.5 (14.8) | 32.8 (11.5) | 32.2 (13.0) |
| State-Trait Anxiety Inventory Traitn | 41.8 (10.1) | 38.6 (6.8) | 40.2 (8.6) |
| Satisfaction With Life Scaleo | 23.4 (6.7) | 22.0 (5.3) | 22.7 (6.0) |
Abbreviation: T4, levorotatory thyroxine.
Data are presented as the mean (SD).
Sixteen participants received placebo at the first study visit and kisspeptin at the second study visit; 16 participants received kisspeptin at the first study visit and placebo at the second study visit.
Calculated as weight in kilograms divided by height in meters squared.
Scored on a scale from 0 to 5, where 0 indicates very unsatisfied and 5 very satisfied.
Sensitivity to anticipation of punishment (score range, 1-28; higher scores indicate greater motivation to avoid aversive outcomes).
Sensitivity to desired goals, fun, and reward (score ranges: drive, 1-16; fun, 1-16; and reward, 1-20; higher scores indicate greater motivation to approach goal-orientated outcomes).
Anxiety screening (score range, 0-21; scores ≥5 indicate anxiety).
Domains of male sexual function (score ranges: erectile function, 0-30; orgasmic function, 0-10; sexual desire, 0-10; intercourse satisfaction, 0-15; and overall satisfaction, 0-10; higher scores indicate better sexual function).
Depression screening (score range, 0-27; scores ≥5 indicate depression).
Dyadic (ie, with a partner) and solitary sexual desire (score ranges: dyadic domain, 0-62; solitary domain, 0-23; and total, 0-109; higher scores indicate higher sexual desire).
Sex-related distress in men (score ranges: desire distress, 0-4; and total, 0-48; higher scores indicate higher sex-related distress).
Overall subjective happiness (score range, 1-7; higher scores indicate greater happiness).
Effect of sexual dysfunction on quality of life (score range, 11-66; higher scores indicate better sexual quality of life).
Trait anxiety (score range, 20-80; higher scores indicate higher levels of anxiety).
Satisfaction with life as a whole (scores range, 5-35; higher scores indicate higher satisfaction with life).