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. 2023 Feb 4;14:620. doi: 10.1038/s41467-023-36279-5

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

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Fig. 2 — A DIC images of platelets in the presence of different amounts of S protein plated onto collagen I-coated surfaces. Scale bar: 5 µm. B Quantification of the aspect ratio of platelets on collagen I-coated surfaces, without and in the presence of different S protein concentrations. The median aspect ratio is shown below the corresponding violin plot. The significance was determined by two-tailed Mann–Whitney U test. n = 442 (control), n = 359 (0.2 µg/ml S protein), n = 443 (2 µg/ml S protein), n = 391 (20 µg/ml S protein) platelets examined over at least three independent experiments from different donors. Each dot represents the value from a single platelet. C Quantification of the circularity of platelets on collagen I-coated surfaces, without and in the presence of different S protein concentrations. The median circularity is shown below the corresponding violin plot. The significance was determined by two-tailed Mann–Whitney U test. n = 442 (control), n = 359 (0.2 µg/ml S protein), n = 443 (2 µg/ml S protein), n = 391 (20 µg/ml S protein) platelets examined over at least three independent experiments from different donors. Each dot represents the value from a single platelet. The plots for control and in the presence of 20 µg/ml spike protein in B and C are same as those in Fig. 1D and E, respectively. D Quantification of platelet activation on Collagen I depending on S protein concentration. The median percentage of the activation is shown below the corresponding dot plot. The significance was determined by two-tailed Mann–Whitney U test. n = 442 (control), n = 359 (0.2 µg/ml S protein), n = 443 (2 µg/ml S protein), n = 391 (20 µg/ml S protein) platelets examined over at least three independent experiments from different donors. Each dot represents the value from a single platelet. Each dot represents the value from a series of experiment. Source data are available as a Source Data file.