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. 2023 Feb 4;14:620. doi: 10.1038/s41467-023-36279-5

Fig. 3. Cryo-electron tomograms of platelets alone and in the presence of SARS-CoV-2 S protein on a collagen I support.

Fig. 3

A, B Low magnification views of a platelet in the presence of S protein on collagen I. The dashed box in B represents the area of tomographic data collection in C. C Tomographic slice of the platelet protrusion in the presence of S protein. D, E Low magnification views of a platelet on collagen I. The dashed box in E represents the area of tomographic data collection in F. F Representative slice of the reconstructed tomogram of platelet plasma membrane. G Magnification of the filopodial structure from C with actin filaments running along the protrusion. H Angular arrangement of actin filaments along the platelet protrusion. I Length of the traced actin filaments of the tomographic reconstruction in G. J Length distribution of traced actin filaments depicted in I. Actin filaments ≥100 nm (12 in total) are not represented in the graph. K Magnified views on the platelet plasma membrane without and in the presence of S protein (E - extracellular, I –intracellular). Scale bars: A, D = 1 µm; B, E = 0.5 µm; C, F, G = 200 nm; K = 20 nm. Source data are available as a Source Data file.