Table 3.
Baseline characteristics and comorbidities based on age in patients with idiopathic pulmonary fibrosis
| Total (n = 21,111) | Older age (≥ 70 years) (n = 12,762) | Younger age (< 70 years) (n = 8349) | p value | |
|---|---|---|---|---|
| Respiratory diseases | ||||
| COPD | 7882 (37.34%) | 5027 (39.39%) | 2855 (34.20%) | < 0.001 |
| Lung cancer | 706 (3.34%) | 430 (3.37%) | 276 (3.31%) | 0.802 |
| Pulmonary embolism | 338 (1.60%) | 245 (1.92%) | 93 (1.11%) | < 0.001 |
| Pulmonary hypertension | 315 (1.49%) | 175 (1.37%) | 140 (1.68%) | 0.073 |
| Obstructive sleep apnoea | 65 (0.31%) | 34 (0.27%) | 31 (0.37%) | 0.179 |
| Non-respiratory diseases | ||||
| GERD | 14,953 (70.83%) | 9065 (71.03%) | 5888 (70.52%) | 0.427 |
| Dyslipidaemia | 13,286 (62.93%) | 8289 (64.95%) | 4997 (59.85%) | < 0.001 |
| Hypertension | 12,464 (59.04%) | 8595 (67.35%) | 3869 (46.34%) | < 0.001 |
| Diabetes mellitus | 9483 (44.92%) | 6245 (48.93%) | 3238 (38.78%) | < 0.001 |
| Ischaemic heart disease | 5431 (25.73%) | 3825 (29.97%) | 1606 (19.24%) | < 0.001 |
| Anxiety | 4238 (20.07%) | 2915 (22.84%) | 1323 (15.85%) | < 0.001 |
| Depression | 3142 (14.88%) | 2222 (17.41%) | 920 (11.02%) | < 0.001 |
| Congestive heart failure | 2887 (13.68%) | 2152 (16.86%) | 735 (8.80%) | < 0.001 |
| CCI | < 0.001 | |||
| 0 | 577 (2.73%) | 230 (1.80%) | 347 (4.16%) | |
| 1 | 3109 (14.73%) | 1532 (12.00%) | 1577 (18.89%) | |
| 2 | 4109 (19.46%) | 2250 (17.63%) | 1859 (22.27%) | |
| 3 | 3823 (18.11%) | 2287 (17.92%) | 1536 (18.40%) | |
| ≥ 4 | 9493 (44.97%) | 6463 (50.64%) | 3030 (36.29%) | |
| CCI, mean (standard deviation) | 3.67 (2.40) | 3.99 (2.48) | 3.20 (2.20) | < 0.001 |
All values are presented as number (%)
CCI Charlson comorbidity index, COPD chronic obstructive pulmonary disease, GERD gastro-oesophageal reflux disease
P values calculated by chi-square tests or Wilcoxon rank sums test