Table 3.
Analysis of the interaction of GBD and cardiometabolic risk factors associated with CVD
| Subgroup | CVD Events | Person-Years | Rated | HRa(95%CI) | HRb(95%CI) | HRc(95%CI) | |
|---|---|---|---|---|---|---|---|
| GBD | Hypertension | ||||||
| - | - | 414 | 35,591 | 116.32 | 1.00 (reference) | 1.00 (ref.) | 1.00 (ref.) |
| - | + | 385 | 12,842 | 299.8 | 2.58 (2.25,2.97) | 1.89 (1.64,2.18) | 1.82 (1.58,2.11) |
| + | - | 150 | 3093 | 484.97 | 4.17 (3.46,5.02) | 2.76 (2.28,3,35) | 2.65 (2.19,3.23) |
| + | + | 251 | 1790 | 1402.23 | 11.80 (10.08,13.81) | 6.02( 5.09,7.12) | 5.58 (4.71,6.62) |
| GBD | T2DM | ||||||
| - | - | 681 | 46,083 | 147.78 | 1.00 (reference) | 1.00 (ref.) | 1.00 (ref.) |
| - | + | 118 | 2350 | 502.13 | 3.40(2.79,4.13) | 2.28 (1.87,2.77) | 2.12 (1.74,2.58) |
| + | - | 337 | 4380 | 769.41 | 5.15(4.52,5.87) | 3.39 (2.96,3.89) | 3.21 (2.80,3.69) |
| + | + | 64 | 503 | 1272.37 | 8.54(6.61,11.03) | 3.94 (3.03,5.140 | 3.50 (2.68,4.56) |
| GBD | Dyslipidemia | ||||||
| - | - | 474 | 34,761 | 136.36 | 1.00 (reference) | 1.00 (ref.) | 1.00 (ref.) |
| - | + | 325 | 13,672 | 237.12 | 1.74 (1.51,2.00) | 1.34 (1.16,1.55) | 1.10 (0.94,1.28) |
| + | - | 224 | 2993 | 748.41 | 5.43 (4.63,6.36) | 3.31 (2.81,3.91) | 3.00 (2.54,3.56) |
| + | + | 177 | 1890 | 936.51 | 6.81 (5.73,8.10) | 3.80 (3.18,4.54) | 2.98 (2.46,3.60) |
| GBD | Overweight | ||||||
| - | - | 193 | 20,661 | 93.41 | 1.00 (reference) | 1.00 (ref.) | 1.00 (ref.) |
| - | + | 606 | 27,772 | 218.21 | 2.34 (1.99,2.75) | 1.62 (1.37,1.90) | 1.27 (1.24,1.73) |
| + | - | 77 | 1305 | 590.04 | 6.26 (4.80,8.15) | 3.45 (2.63,4.52) | 3.41 (2.60,4.47) |
| + | + | 324 | 3578 | 905.54 | 9.60 (8.03,11.48) | 4.79 (3.98,5.77) | 4.05 (3.35,4.89) |
| GBD | Abdominal obesity | ||||||
| - | - | 184 | 20,599 | 89.32 | 1.00 (reference) | 1.00 (ref.) | 1.00 (ref.) |
| - | + | 615 | 27,834 | 220.95 | 2.48 (2.10,2.92) | 1.58 (1.34,1.87) | 1.25 (1.04,1.50) |
| + | - | 71 | 1224 | 580.07 | 6.41 (4.87,8.43) | 4.41 (3.34,5.81) | 4.28 (3.24,5.65) |
| + | + | 330 | 3659 | 901.89 | 10.01 (8.36,12.00) | 4.48 (3.69,5.43) | 3.30 (2.68,4.06) |
Model a was unadjusted
Model b was adjusted for age and sex
Model c was further adjusted for exercise, hypertension, T2DM, overweight, and HDL levels
d Rate per 10,000 person-years. (GBD gallbladder disease, T2DM type 2 diabetes mellitus, CVD cardiovascular disease, HDL high-density lipoprotein cholesterol)