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. 2023 Feb 2;67:10.29219/fnr.v67.8694. doi: 10.29219/fnr.v67.8694

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© 2023 Weipeng Wang et al.

This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material for any purpose, even commercially, provided the original work is properly cited and states its license.

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Fig. 2 — IP6 improves histological adaptation of the residual intestine in the SBS rats. (a) Representative images of hematoxylin-eosin (HE) staining of the proximal small intestine of rats in different groups (n = 10 per group). Scale bars, 250 μm. (b) Comparison of villus height in the proximal small intestine of rats in different groups (n = 10 per group). (c) Comparison of crypt depth in the proximal small intestine of rats in different groups (n = 10 per group). (d) Representative images of HE staining of the distal small intestine of rats in different groups (n = 10 per group). Scale bars, 250 μm. (e) Comparison of villus height in the distal small intestine of rats in different groups (n = 10 per group). (f) Comparison of crypt depth in the distal small intestine of rats in different groups (n = 10 per group). (g) Comparison of muscle thickness in the distal small intestine of rats in different groups (n = 10 per group). (h) The relative mRNA expression levels of Gcg of the mucosa in the distal small intestine (n = 6 per group). Values were normalized to Actb expression. (i) The levels of glucagon-like peptide-2 (GLP-2) in the serum were evaluated by ELISA analysis (n = 6 per group). Values are mean ± SEM; ns, not significant; * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001, SBS group versus Sham group; ^# P < 0.05, ^## P < 0.01, ^### P < 0.001, ^#### P < 0.0001, SBS + IP6 group versus SBS group.