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. 2023 Feb 4;8:9. doi: 10.1038/s41541-023-00604-2

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Neurobehavioural changes were assessed in Lewis rats before (•) and after injection of (▪) PBS, rM5, P*17-DT and K4S2-DT using the following tests: a food manipulation, b beam walking, c grooming, d marble burying and e–g light/dark box test (LDB). LDB was performed after injection of PBS (•), rM5 (▪), P*17-DT (▴) and K4S2-DT (♦). In each experiment (n = 6), age-matched rats were used. Statistical analysis performed by two-way ANOVA. Significance to control group, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Error bars represent standard deviation.