Figure 7.

mTORC1 signaling is altered by lumateperone. A, Male adult rats received either lumateperone (3 mg/kg, intraperitoneal) or vehicle on days 1 and 2. Sample collection happened on day 3. B, Representative immunoblots for the two groups. C, Quantitative results of phospho (p) protein immunoblots are based on total levels of protein for each particular kinase. Lumateperone differentially alters the phosphorylation of Akt, mTOR, and P70S6K in the PFC while changes are not observed at this time point in the hippocampus. Data were collected using Western blot analysis. Results are mean ± SEM; n = 19 or 20 per group. *p < 0.05 compared with the control vehicle group (two-tailed Student's t tests). Hipp, hippocampus; Luma, lumateperone; mTOR, mammalian target of rapamycin; PFC, prefrontal cortex; Veh, vehicle.