Table 3.

Behavioral tests to measure anxiety in naive rats injected with lumateperone^a

	Control	Luma	Statistical test	p
NSFT (s)	657.8 ± 60.4	507.9 ± 55.7	Mann–Whitney U	0.0009***
Control HCFT (g)	6.0 ± 0.5	6.0 ± 0.3	Unpaired t test	0.9897 (NS)
NIH, novel cage (s)	65.4 ± 16.4	30.5 ± 13.8	Mann–Whitney U	0.0257*
OFT (m)	17.2 ± 3.4	32.8 ± 10.2	Unpaired t test	0.8879 (NS)

^aTwo doses of lumateperone (1 mg/kg) were administered on different days to a cohort of naive rats to assess anxiety-like behavior. Anxiety was investigated with NSFT paired with its control, HCFT, and NIH was measured in an empty novel cage. Locomotion was assessed in an open field. Data are mean ± SEM; n = 5–14 per group.

*p < 0.05,

***p < 0.001, compared with control group. Luma, lumateperone; NS, not significant.