Table 2.
Morphologic data from retrovirally infected granule neurons
| Genotype | Cre | Soma size (mean ± SEM; µm2) | p | n, cells (animals) |
|---|---|---|---|---|
| Ptenflx/flx | – | 102.40 ± 2.94 | <0.0001 | 57 (6) |
| Ptenflx/flx | + | 181.24 ± 5.80 | 55 (6) | |
| Ptenflx/flxRictorflx/flx | – | 91.85 ± 1.28 | <0.0001 | 141 (6) |
| Ptenflx/flxRictorflx/flx | + | 136.55 ± 1.83 | 240 (6) | |
| Ptenflx/flx | + | 181.24 ± 5.80 | <0.0001 | 55 (6) |
| Ptenflx/flxRictorflx/flx | + | 136.55 ± 1.83 | 240 (6) | |
| Migration (mean ± SEM; % GCL) | ||||
| Ptenflx/flx | – | 0.340 ± 0.01 | <0.0001 | 57 (6) |
| Ptenflx/flx | + | 0.583 ± 0.01 | 55 (6) | |
| Ptenflx/flxRictorflx/flx | – | 0.311 ± 0.02 | <0.0001 | 54 (6) |
| Ptenflx/flxRictorflx/flx | + | 0.409 ± 0.01 | 142 (6) | |
| Ptenflx/flx | + | 0.583 ± 0.01 | <0.0001 | 55 (6) |
| Ptenflx/flxRictorflx/flx | + | 0.409 ± 0.01 | 142 (6) | |
| Spine density (mean ± SEM; #) | ||||
| Ptenflx/flx | – | 2.09 ± 0.06 | <0.0001 | 32 (4) |
| Ptenflx/flx | + | 4.54 ± 0.30 | 38 (4) | |
| Ptenflx/flxRictorflx/flx | – | 1.30 ± 0.08 | <0.0001 | 22 (4) |
| Ptenflx/flxRictorflx/flx | + | 1.68 ± 0.12 | 34 (4) | |
| Ptenflx/flx | + | 4.54 ± 0.30 | 0.370 | 38 (4) |
| Ptenflx/flxRictorflx/flx | + | 1.68 ± 0.12 | 34 (4) | |
| Dendritic length (mean ± SEM; µm) | ||||
| Ptenflx/flx | – | 1056.29 ± 45.08 | <0.0001 | 24 (4) |
| Ptenflx/flx | + | 1634.42 ± 62.69 | 26 (4) | |
| Ptenflx/flxRictorflx/flx | – | 1206.77 ± 71.37 | <0.01 | 15 (3) |
| Ptenflx/flxRictorflx/flx | + | 1206.17 ± 58.62 | 18 (3) | |
| Ptenflx/flx | + | 1634.42 ± 62.69 | 1.000 | 26 (4) |
| Ptenflx/flxRictorflx/flx | + | 1206.17 ± 58.62 | 18 (3) | |
| Primary dendrites (mean ± SEM; #) | ||||
| Ptenflx/flx | – | 1 ± 0 | <0.0001 | 24 (4) |
| Ptenflx/flx | + | 2.69 ± 0.14 | 26 (4) | |
| Ptenflx/flxRictorflx/flx | – | 1.125 ± 0.08 | <0.05 | 16 (3) |
| Ptenflx/flxRictorflx/flx | + | 1.66 ± 0.16 | 18 (3) | |
| Ptenflx/flx | + | 2.69 ± 0.14 | <0.0001 | 26 (4) |
| Ptenflx/flxRictorflx/flx | + | 1.66 ± 0.16 | 18 (3) |