Table 4.
Intrinsic electrophysiological properties of cultured neurons
| Property | Control (mean ± SEM) | Pten LOF (mean ± SEM) | Pten-Rictor LOF (mean ± SEM) | GEE p |
|---|---|---|---|---|
| Input resistance (mΩ) | 301.8 ± 23.6 | 190.1 ± 16.5 | 268.8 ± 23.9 | 0.0021 |
| Capacitance (pF) | 81.1 ± 5.3 | 123.7 ± 9.9 | 105.8 ± 7.6 | 0.0011 |
| Rheobase (pA) | 124.3 ± 24.2 | 244.7 ± 30.1 | 106.7 ± 13.5 | 0.0003 |
| AP threshold (mV) | −36.1 ± 1.87 | −35.6 ± 1.9 | −40.7 ± 2.96 | 0.038 |
| AP amplitude (mV) | 70.4 ± 2.8 | 73.3 ± 3.3 | 77.0 ± 3.6 | 0.512 |
| AP half-width (ms) | 2.08 ± 0.22 | 2.03 ± 0.19 | 1.95 ± 0.15 | 0.248 |