Table 2.
Pooled analysis of studies comparing full-dose heparin anticoagulation to prophylactic or intermediate dose anticoagulation
| Outcomes | Events/patients full-dose anticoagulation (%) | Events/patients prophylactic or intermediate dose anticoagulation (%) | Risk ratio (95% CI) | P-value | I2 (%) | Probability RR < 1* (%) | Probability NNT* ≤ 100*(%) |
|---|---|---|---|---|---|---|---|
| Primary outcome | |||||||
| All-cause mortality at the longest follow-up available | 103/1662 (6.2%) | 126/1635 (7.7%) | 0.76 (0.59–0.98) | 0.037 | 43% | 98.2 | 84.5 |
| Secondary outcomes | |||||||
| Major thrombotic events (arterial and venous) | 25/1662 (1.5%) | 63/1635 (3.9%) | 0.41 (0.26–0.64) | ˂ 0.001 | 0% | 99.9 | 99.5 |
| Major bleeding events | 29/1662 (1.7%) | 22/1636 (1.3%) | 1.42 (0.80–2.51) | 0.23 | 9% | 88.4 | 24.4 |
| Need for mechanical ventilation | 163/1631 (10.0%) | 169/1606 (10.5%) | 0.90 (0.73–1.10) | 0.30 | 2% | 84.4 | 52.0 |
| Need for ICU admission | 190/1663 (11.4%) | 199/1639 (12.1%) | 0.93 (0.77–1.12) | 0.42 | 0% | 77.6 | 44.4 |
ICU intensive care unit, CI confidence interval
*RR > 1 and NNH for bleeding