Table 10:

Volume of Thrombolytic Infusion With Mechanical Thrombectomy Use in Arterial Acute Limb Ischemia

Author, year	Outcome measurement	Results		P value
		MT	Comparator
PMT (AngioJet)
de Athayde Soares et al, 202077	Unfractionated heparin use postoperatively	NR	NR	P = .15
	IV prostavasin	11% (2)	6% (2)	P = .40
Gong et al, 20211 Included large bore catheters, AngioJet, and Rotarex]	Mean rtPA dose	14.14 mg (SD ± 5.75)	29.27 mg (SD ± 11.70)	P = .000
Vacuum Aspiration (Indigo)
No studies met our inclusion criteria for this mechanical thrombectomy device
Rotational (Rotarex)
Gong et al, 2021,1 included large bore catheters, AngioJet, and Rotarex (see findings discussed elsewhere in this assessment)a
Muli Jogi et al, 2018,82 included both AngioJet and Rotarex (see findings discussed elsewhere in this assessment)a
Puangpunngam et al, 202083	Dose of rtPA	0	30 mg	P = .001
Ultrasound Assisted (EKOS)
Chait et al, 201974,c	Mean volume of tPA administered	48.2 mg	44.6 mg	P = .6
Schernthaner et al, 201484	Median total rtPA lytic dose	8.4 mg (IQR: 4.9-13.2)	6.8 (IQR: 5.8-11.1)	P = .479

Abbreviations: IQR, interquartile range; PMT, pharmacomechanical thrombectomy; NR, not reported; PMT, pharmacomechanical thrombectomy; SD, standard deviation.

^aGong et al¹ compared treatment groups of large bore catheters versus AngioJet versus Rotarex.

^bMuli Jogi et al, 2018⁸² compared catheter-directed thrombolysis versus AngioJet and Rotarex.

^cWhile all patients in both groups also received AngioJet, the study design isolated the effect of EKOS.