Table 11:
Time of Thrombolytic Infusion With Mechanical Thrombectomy Use in Arterial Acute Limb Ischemia
| Results | ||||
|---|---|---|---|---|
| Author, year | Outcome measurement | MT | Comparator | P value |
| PMT (AngioJet) | ||||
| Byrne et al, 201476 | Mean duration of lysis | Among those who received PMT and lysis (n = 56) Mean time: 23.6 h |
Mean time: 25.5 h | P =.445 |
| de Athayde Soares et al, 202077 | Mean duration of procedure | NRa | 12 h (range 1-36 h) | NR |
| Gandhi et al, 201879 | Lysis time, mean | 2.03 d (SD ± 1.65) | 2.38 d (SD ± 2.65) | P = .58 |
| Proportion of patients who required > 24 h lysis time | 56.4% (22) | 57.1% (12) | P = .96 | |
| Gong et al, 20211 Included large bore catheters, AngioJet, and Rotarex |
Mean duration of operation procedureb Mean total duration of thrombolysis |
1.89 h (SD ± 0.52) 1.74 d (SD ± 0.98) |
1.32 h (SD ± 0.44) 3.07 d (SD ± 1.38) |
P = .000 P = .00 |
| Vacuum Aspiration (Indigo) | ||||
| No studies met our inclusion criteria for this mechanical thrombectomy device | ||||
| Rotational (Rotarex) | ||||
| Gong et al, 2021,1 included large bore catheters, AngioJet, and Rotarex | ||||
| Puangpunngam et al, 202083 | Time to lysis | 0 | 40 h | P = .001 |
| Ultrasound Assisted (EKOS) | ||||
| Chait et al, 201974,c | Mean duration of thrombolysis | 45.6 h (SD ± 22.1) | 39.6 h (SD ± 19.9) | P = .22 |
| Schernthaner et al, 201484 | Median total rtPA infusion time | 23 h (IQR: 20.5-38.0) | 23 h (IQR: 20.3-32.3) | P = .787 |
Abbreviations: IQR, interquartile range; MT, mechanical thrombectomy; NR, not reported; PMT, pharmacomechanical thrombectomy; SD, standard deviation.
a
Reported following protocol of 20-min dwell time and 300-s activation.
b
Large-bore catheters had slightly shorter procedure lengths than the AngioJet or Rotarex.
c
While all patients in both groups also received AngioJet, study design was isolating the effect of EKOS.