Table 16:
Post Thrombotic Syndrome With Mechanical Thrombectomy Use in Acute and Subacute DVT in Observational Studies
| Results | ||||
|---|---|---|---|---|
| Author, year | Outcome measurement | MT | Comparator | P value |
| PMT (AngioJet) | ||||
| Huang et al 201596 | Villalta score at 12 mo | 2.06 (SD ± 2.95) | 5.06 (SD ± 4.07) | P = .030 |
| Venous reflux at 12 mo | 1.31 (SD ± 0.48) | 1.39 (SD ± 0.61) | P = .851 | |
| Huang et al, 202197 | PTS, by 5-y follow up | 45.0% (n = 27) | 57.7% (n = 34) | P = .201 |
| Severe PTS (Villalta score ≥ 15) by 5-y follow up | 11.7% (n = 7) | 27.1% (n = 16) | P = .039 | |
| Kuo et al, 201798 | Post-thrombotic syndrome | 20% (n = 6) | 19.4% (n = 6) | P = 1.0 |
| Villalta score | 1.87 (SD ± 2.7) | 3.13 (SD ± 3.0) | P = .042 | |
| Lee et al, 202099 | Villalta score at 6 mo | 1.12 (SD ± 0.92) | 1.47 (SD ± 1.24) | P = .372 |
| Pouncey et al, 2020103 | PTS at 6 mo | 21.4% (n = 15) | 24.6% (n = 20) | P = .64 |
| PTS at 1 y | 20% (n = 14) | 22.2% (n = 18) | P = .74 | |
| Villalta score at 1 ya | 1 (range: 0-3) | 3 (range: 3-4) | P = .31 | |
| Tian et al, 2021105 | Villalta score at 24 mo | 3.65 (SD ± 2.73) | 3.70 (SD ± 0.62) | P = .225 |
| Post-thrombotic syndrome at 24 mo | 0 | 4% (n = 2) | P = .493 | |
| Xu et al, 2021107 | Patients who developed PTS (Villalta score > 5) Median 19-mo follow up | 5.5% (n = 10) | 15.3% (n = 31) | P < .05 |
| Estimate of incidence of PTS at 4 y | 19.8% | 60% | Kaplan-Meier curve NR |
|
| Xu et al, 2020108 | Incidence of PTS at 12 mo | 20% (n = 6) | 29.5% (n = 13) | P = .852 |
| Vacuum Aspiration (Indigo) | ||||
| No studies met our inclusion criteria for this mechanical thrombectomy device | ||||
| Rotational (Rotarex or Cleaner) | ||||
| Ezelsoy et al, 201595 | Rate of post-thrombotic syndrome | 28% (n = 7) | 56% (n = 14) | P = .045 |
| Ultrasound Assisted (EKOS) | ||||
| Tichelaar et al, 2016106 | Proportion with severe post-thrombotic syndromeb |
5% (n = 1) | 10% (n = 5) | NS |
Abbreviations: DVT, deep vein thrombosis; MT, mechanical thrombectomy; PMT, pharmacomechanical thrombectomy; NR, not reported; NS, not significant; PTS, post-thrombotic syndrome; SD, standard deviation.
a
Similar finding at 6 months.
b
Similar findings for mild and moderate post-thrombotic syndrome.