Table 8:

Mortality With Mechanical Thrombectomy Use in Arterial Acute Limb Ischemia

Author, year	Outcome measurement	Results		P value
		MT	Comparator
PMT (AngioJet)
Byrne et al, 201476	1 y survival 2 y survival Overall 30-d mortality	86% (n = 61) 81% (n = 56) 5.6% (n = 4)	82% (n = 68) 67% (n = 56) 4.8% (n = 4)	P = .341 P = .82
de Athayde Soares et al, 202077	Perioperative mortality	11.1% (n = 2)	19.3% (n = 6)	P = .03
	Multivariate Cox regression analysis of factors associated with survival	Rutherford classification, gender, kidney disease, diabetes, segment occluded, fasciotomy		P > .05
		Type of surgery: CDT related to increased mortality; HR 1.330 (95% CI: 0.542-1.543)		P = .26
	Overall survival at 720 d post intervention	84.7%	69.2%	Kaplan-Meier curve P = .822
Escobar et al, 201778	Perioperative mortality	3.8% (n = 2) Mesenteric ischemia and pulmonary embolus	0	NR
Gandhi et al, 201879	Perioperative mortality	1.9% (n = 1)	0	P = 1.0
Gong et al, 20211 Included large bore catheters, AngioJet, and Rotarex	Mortality	1.8% (n = 1)	2.4% (n = 1)	P = 1.0
Muli Jogi et al, 201882 Included both AngioJet and Rotarex]	Overall 30-d mortality	3.6% (n = 1)	8% (n = 7)	P = .425
Vacuum Aspiration (Indigo)
No studies met our inclusion criteria for this mechanical thrombectomy device
Rotational (Rotarex)
Gong et al, 202,11 included large bore catheters, AngioJet, and Rotarex (see findings discussed elsewhere in this assessment)a
Hundt et al, 201380	Mortality	0	0	NS
Kronlage et al, 201781	Survival among non-critically ill, at 12 mo	Overall survival across study group: 96.02%b		Kaplan-Meier curve P = .86
	Survival among critically ill, at 12 mo	Overall survival across study group: 65%b		Kaplan-Meier curve P = .12
Muli Jogi et al, 2018,82 included both AngioJet and Rotarex (see findings discussed elsewhere in this assessment)c
Ultrasound Assisted (EKOS)
Chait et al, 201974,d	30-d mortality	4% (n = 1)	4% (n = 3)	P = .97
Schernthaner et al, 201484	Perioperative mortality	0	0	NS
	Event free survival	Median event-free survival: 43 mo (range: 29-64 mo)	Median event-free survival: 21 mo (range: 16-59 mo)	P = .061

Abbreviations: CDT, catheter-directed thrombosis; CI, confidence interval; HR, hazard ration; MT, mechanical thrombectomy; NR, not reported; NS, not significant; PMT, pharmacomechanical thrombectomy.

^aGong et al¹ compared treatment groups of large bore catheters versus AngioJet versus Rotarex.

^bData for each study group presented as Kaplan-Meier curves, specific details not provided.

^cMuli Jogi et al, 2018⁸² compared catheter-directed thrombolysis versus AngioJet and Rotarex.

^dWhile all patients in both groups also received AngioJet, the study was designed to isolate the effects of EKOS.