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. 2023 Feb 4;13:2025. doi: 10.1038/s41598-023-28666-1

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2023

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Routine use of MRI contrast agent resulted in intracellular gadolinium-rich nanoparticles. (a) Electron-dense intracellular precipitates (arrows) in human kidney. Hitachi H7700 TEM, AMT 16-megapixel digital camera. Calibration bars = 5 µm. (b) (Left) Darkfield scanning transmission electron micrograph of an electron-dense precipitate from the kidney specimen depicted in (a). (Right) 2D XEDS map of the nanoparticle in (b). (c) 2D XEDS mapping for gadolinium, calcium, phosphorus, sulfur, chlorine, and iron of the nanoparticle shown in (b). (d) XEDS line scan through the particle shown in (b). JEOL NEOARM 200 kV aberration-corrected scanning transmission electron microscope with dual EDS x-ray analysis system.