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. 2023 Feb 4;9:43. doi: 10.1038/s41420-022-01294-w

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© The Author(s) 2023, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A The survival rate of mice treated with DOX (n = 5). B The weights of mice treated with DOX for 3 days (n = 5). C Macroscopic observation of mouse heart after 3 days of DOX treatment. D Effect of DOX on the ratio of heart weight to tibia in mice (n = 4). E M-mode ultrasonic image and LVEF%, LVFS% statistical chart of short-axis section of mouse heart before and after DOX treatment (n = 5). F, G Two-dimensional speckle tracking technology displayed the diastolic phase (red) and systolic phase (blue) of the wall motion monitored by each tracer point shown in the figure. H Western blot was used to detect the expression of apoptosis-related proteins and NSUN2 protein in the heart tissues of two groups (n = 3). I Immunohistochemistry was used to detect the expression of NSUN2 in the myocardium of DOX treatment group and saline group (Bar = 100 µm). The survival rate was analyzed by survival curve, the measurement data were shown as mean ± standard deviation, and compared by Student’s t-test. *P < 0.05; **P < 0.01; ***P < 0.001.