Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Feb 4;14:610. doi: 10.1038/s41467-023-35995-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a Site distribution of the sequenced samples. The number of samples from each site is shown in brackets. b The sequencing strategy across all samples. c An overview of somatic mutations detected in primary tumour, regional lymph node metastasis and distant metastasis samples. The top panel shows the total mutations for each sample. The middle panel shows the mutation details for putative driver genes. The significantly mutated genes evaluated by MutSigCV are shown in blue, and the genes with significantly different frequencies in primary tumours and regional lymph node or distant metastasis are marked with asterisks (Pri vs. Lyn in yellow and Pri vs. Met in red). Clinical information is shown in the bottom panel. d The CNV landscape of primary tumour, regional lymph node metastasis and distant metastasis samples. The height of each bar refers to the G-score. Important frequently altered genes are highlighted. Source data are provided as a Source Data file.